
王敏,男,1987年12月出生,江蘇儀征人,理學博士,副教授,碩士生導師,畢業于中國科學院大學?,F在新材料與化工學院制藥工程系工作。
I. 主要研究工作
1. 微生物天然產物(藥物)的挖掘;
2. 微生物天然產物生物合成機制;
3. 化學酶法合成重要藥物及其中間體。
II. 承擔科研項目
1. 微生物資源前期開發國家重點實驗室前沿探索課題基金:糖苷類化合物α、β構象轉換的研究,項目負責人,2019-2020。
2. 中國科學院微生物研究所科學研究基金:N-糖苷鍵構象的轉換及其機制的研究,項目負責人,2018-2021。
3. 國家自然科學基金青年科學基金項目:阿維菌素中L-齊墩果糖的生物合成機制研究(項目號:31700036),項目負責人,2018.01-2020.12。
4. 企業橫向項目:五肽熒光標簽的添加與結構表征,項目負責人,2024-2025。
5. 農業農村部植保生物技術重點實驗室開放基金項目:抗小麥病毒農藥先導化合物的挖掘,項目負責人,2024-2025。
III. 代表性學術論文
1. Haoyang Liu, Hailiang Xing, Peilan Yu, Yanjie Wang, Jia-Lei Yan, Junyang Liu,* Min Wang*. Base-Controlled Synthesis of Heteroatom-Embedded Membered Cycloalkynes and Membered Sultams through Copper-Catalyzed Cyclization[J]. J Org Chem, 2025, 90, 2, 984-993.
2. Yue Tang, Xiaoying Tian, Min Wang, Yinglu Cui, Yang She, Zhaoxiang Shi, Jiaqi Liu, Huijin Mao, Lilu Liu, Chao Li, Yuwei Zhang, Pengwei Li, Yue Ma, Jinyuan Sun, Qing Du, Jie Li, Jun Wang, De-feng Li, Bian Wu*, Feng Shao*, Yihua Chen*. The β-D-manno-heptoses are immune agonists across kingdoms[J]. Science, 2024, 385, 678-684.
3. Yunqiang Wu, Min Wang*, Liwei Liu*. Advances on structure, bioactivity, and biosynthesis of amino acid-containing trans-AT polyketides[J]. Eur J Med Chem, 2023, 262, 115890.
4. Yuwei Zhang#, Ge Liao#, Min Wang#, Zhao Zhang#, Liwei Liu, Yuqin Song, Dacheng Wang, Tingting Hao, Jie Feng, Bin Xia, Yixiang Wang, Xiaoyu Tang*, Yihua Chen*. Human associated bacteria adopt an unusual route for synthesizing ;acetylated tetramates for environmental adaptation[J]. Microbiome, 2023, 11: 97.
5. Peishan Li#, Hongmei Lu#, Yanzhu Zhang, Xuejiao Zhang, Lianliang Liu, Min Wang*, Liwei Liu*. The natural products discovered in marine sponge-associated microorganisms: structures, activities, and mining strategy[J]. Front Mar Sci, 2023, 10: 1191858.
6. Li Tao#, Min Wang#, Guobo Guan, Yuwei Zhang, Tingting Hao, Chao Li, Shuaihu Li, Yihua Chen, Guanghua Huang*. Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid[J]. Virulence, 2022, 13:1, 542-557.
7. Yue Tang#, Min Wang#, Hua Qin, Xiangxiang An, Zhengyan Guo, Guoliang Zhu, Lixin Zhang, and Yihua Chen*. Deciphering the Biosynthesis of TDP-β-L-oleandrose in Avermectin[J]. J Nat Prod, 2020, 83: 3199-3206.
8. Min Wang#, Zhoujie Xie#, Shoubin Tang#, Ee Ling Chang, Yue Tang, Zhengyan Guo, Yinglu Cui, Bian Wu, Tao Ye, Yihua Chen*. Reductase of mutanobactin synthetase triggers sequential C-C macrocyclization, C-S bond formation, and C-C bond cleavage[J]. Org Lett, 2020, 22: 960-964.
9. Jine Li#, Min Wang#, Yong Ding, Yue Tang, Zhiguo Zhang*, Yihua Chen*. Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins[J]. Sci Rep, 2016, 6: 21180.
10. Tao Ji#, Yanjie Wang#, Min Wang#, Ben Niu#, Ping Xie, Charles U. Pittman, Jr., and Aihua Zhou*. Parallel syntheses of eight-membered ring sultams via two cascade reactions in water[J]. Acs Comb Sci, 2013, 15: 595-600.
11. Min Wang, Yanjie Wang, Xueyong Qi, Guohua Xia, Kun Tong, Jinchang Tu, Charles U. Pittman Jr., and Aihua Zhou*. Selective synthesis of seven- and eight-membered ring sultams via two tandem reaction protocols from one starting material[J]. Org Lett, 2012, 14: 3700-3703.
IV. 發明專利和軟件著作權
1. 陳義華,唐越,王敏。一類保羅霉素衍生物及其制備方法與應用(ZL201810677960.X)。
2. 劉磊,陳天鴿,徐巨才,許敏,徐振崗,陳韜文,干雨澤,魏萍,王敏,袁兆棟,賀天懿。具有緩釋維生素作用的特殊醫學用途配方食品的加工方法(CN 117158578 B)。
3. 劉君羊,劉昊洋,邢海亮,王敏。一種六元環磺酰胺類化合物的制備方法202410937674。
V. 招生信息
本人目前主要招收生物與醫藥(0860)專業學位碩士。誠摯歡迎化學、中藥、生物制藥、藥學等專業踏實認真、敢于創新的同學加入本團隊。