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王學重

日期:2021-10-22 | 點擊量:

姓名

王學重

http://210.31.45.128/publish/huagong/2020-04/202004051905059605482.jpeg

職稱

教授，博士生導師，國家級人才

學歷(學位)

研究生(工學博士)

部門及職務

新材料與化工學院  制藥工程系

辦公電話

 

郵 箱

18818866539@163.com

辦公地址

 

 

王學重，男，1963年生。中國石油大學化學化工學院獲學士（1984）、碩士（1987）和博士學位（1990）。1990-1992任職北京化工大學自動化系講師和副教授，1993年英國從事博士后研究，1995年受聘英國利茲大學化學工程學院講師，之后晉升高級講師(2001)和準教授（2005）并得到曾七次獲得英國女王商業杰出成就獎的馬爾文儀器公司的贊助（Malvern Reader in Intelligent Measurement and Control）。2006年獲聘英國利茲大學化學工程學院過程控制和信息學講席教授（Personal Chair in Process Control and Informatics）。2012年入選國家特聘計劃任職華南理工大學化學化工學院。2019年就職北京石油化工學院化學工程學院。

     科研工作集中在制藥（化學藥、生物藥和中藥）、納米材料、和精細化工的產品、工藝和設備開發，過程放大，模擬，工業生產的監測和智能優化控制。作為項目主持人獲得英國工程和物理研究基金會、歐盟和工業界的科研項目資助超900萬英鎊。2012年回國后獲得縱向和橫向科研項目資助2000余萬元。

     基礎和應用研究的部分成果在工業界得到了應用和技術轉化。在英國期間和世界最大的制藥公司輝瑞，葛蘭素史克，阿斯利康，先正達等20多家企業建立了長期的密切合作關系。他幫助馬爾文儀器開發的分析儀器Morphologi G被利茲大學所在的學院于2012年評選為過去六年中最具工業影響的科研成果的第一名，參與英國每六年一次的科研水平全國評比。2012年回國后和中國的制藥和化工企業也建立了密切的合作（例如廣藥集團白云山制藥、萬華化學、齊魯制藥、中化國際圣奧化學、無限極（中國）、潤都制藥、華海藥業、國邦藥業、中科生物制藥、東陽光藥業、中科院青海鹽湖所、中國工程物理研究院、天津海水淡化所、百會藥業等）。

     發表科研論文200余篇篇，英文專著１部 。論文被引用4300余次。獲得歐洲化學工程協會的會志Chem. Eng. Res. Des. 2006-2009年論文被最多引用獎。指導畢業博士生25名(英國21中國4)，博士后16名，碩士生多人，其中四名博士研究生獲最佳博士研究生論文獎。

  

目前的研究集中在以下幾個方向：

1. 制藥和結晶過程系統工程，基于晶型結構的群體粒數衡算模型模擬結晶器中晶體的生長，實現結晶過程中晶體多維形狀分布的模擬以及組成的模擬；開在線三維圖像獲取和圖像處理技術用于晶體生長過程中三維晶形結構的在線測量；基于上述突破，實現了結晶過程晶體群體形狀分布的閉環自動控制。晶型篩選，智能自動化晶型篩選機器人開發。連續結晶、造粒、研磨設備的研發。

2. 制藥工藝過程全流程的模擬、過程分析技術和控制技術的開發，包括合成、結晶、過濾、造粒、研磨、干燥和壓片等；生物制藥過程例如發酵和細胞培養等工藝的過程分析技術、控制和模擬技術的研究。

3. 在過程工業數據挖掘方面，提出了數據挖掘用于過程檢測和控制，發表英文專著“數據挖掘和知識發現在過程檢測和控制中的應用“（Data Mining and Knowledge Discovery for Process Monitoring and Control – Springer， London，New York，1999）。致力于大數據挖掘和應用于制藥工藝的智能化和自動化制造。

4. 在納米生產過程的在線測量、模擬及控制、放大和高通量新產品開發這一重要領域的相關研究上，研究開發括動態光散射、超聲、近紅外和過程層析成像儀器，和群體粒數衡算模型和計算流體力學模擬等。

5. 此外，研究工作還包括利用構效關系模型（SAR – structure activity relationship）預測納米材料毒性。

     主要科研項目： 

  1. 廣東省科技廳：藥物晶體制備過程中的晶型晶習多目標優化控制， 2016.1-2018.12。

  2. 國家自然科學基金重大研究計劃“多相反應過程中的介尺度機制及調控"：結晶和反應結晶過程的介尺度機理研究和模擬調控，2015.1-2017.12。

  3. 國家自然科學基金委重點項目：基于紅外光譜和圖像信息的工業結晶過程在線監測與控制優化，2017.1 -2021.12。

  4. 歐盟框架7大型合作項目：SUN Project – Sustainable Nanotechnologies，2014.1 - 2017.3。

  5. 英國工程和物理科學研究基金委: Processing Nanoparticles in Suspension of High Solid Concentration: On-line Characterisation and Process Modelling，2010.9-2014.8。

  6. 英國Technology Strategy Board項目：High Value Manufacturing - Process Integration and Product Enhancement Through Crystal Growth Modifiers，2009.1-2013.9。

  7. 歐盟框架7大型合作項目：MARINA - Reference Methods for Managing the Risk of Engineered Nanoparticles, 2011.11-2015.5。

  8. 英國工程和物理科學研究基金委: Continuous Hydrothermal Synthesis of Nanomaterials: From Laboratory to Pilot Plant, 2008.7-2011.10。

  9. 企業合作項目：廣藥集團白云山制藥、中華國際圣奧化學、萬華化學集團、華海藥業、國邦藥業、東陽光藥業、中科生物、齊魯制藥、無限極（中國）、百會制藥、瑞陽制藥、潤都制藥等， 2012.10-2018.12

 

代表性學術論著：

 

  1. Yi Dan Shu, Jing Jing Liu, Yang Zhang and Xue Zhong Wang*，Multi-stage Multi-component Transfer Rate Morphological Population Balance Model for Crystallisation Processes，CrystEngComm. 2019, 21(28)，4212-4220.

  2. Shuai Yu, Yang Zhang, and Xue Zhong Wang, Improved Understanding of Cefixime Trihydrate Reactive Crystallization and Process Scale-up with the Aid of PAT. Organic Process Research & Development. 2019, 23(2), 177–188.

  3. Ningxin Zhan, Yang Zhang, Xue Zhong Wang, Solubility of N-tert-Butylbenzothiazole-2-sulfenamide in several pure and binary solvents. Journal of Chemical & Engineering Data. 2019, 64(3), 1051-1062.

  4. F Zhang, T Liu, W Chen, CY Ma, XZ Wang，Seed Recipe Design for Batch Cooling Crystallization with Application to L-Glutamic Acid. Industrial & Engineering Chemistry Research， 2019， 58 (8), 3175-3187

  5. 呂鳳，張揚，馬才云，王學重，甘露醇噴霧干燥過程中液滴粒度分布變化的群體粒數衡算模擬和實驗研究，化工進展，2019, 38(2):  772-778

  6. YD Shu, Y Li, Y Zhang, L Jing J., XZ Wang, A multi-component mass transfer rate based model for simulation of non-equilibrium growth of crystals. CrystEngComm, 35(21), 5081-5282. 20 (35), 5143-5153

  7. XHT Tang, JJ Liu, Y Zhang, XZ Wang，Study on the influence of lysozyme crystallization conditions on crystal properties in crystallizers of varied sizes when temperature is the manipulated variable. Journal of Crystal Growth 498, 186-196

  8. 李亞軍， 王學重， 集成過程分析技術和群體粒數衡算模擬的藥物材料造粒過程決策支持系統, 材料導報, 2018, 31 (10), 1721-1729

  9. 李晶晶， 周昭露， 黃生權， 魯亮， 黃延盛， 田淑華， 李璇， 李杰， 舒逸聃, 近紅外光譜技術應用于中草藥口服液在線質量控制的化學計量學建模. 化工進展, 2018, 37 (5), 1923-1932

  10.  YJ Li, K Wu, Y Li, Y Zhang, JJ Liu, XZ Wang, Solubility in Different Solvents, Crystal Polymorph and Morphology, and Optimization of Crystallization Process of AIBN. Journal of Chemical & Engineering Data, 2018, 63 (1), 27–38

  11. Xi H. Tang, Yang Li, Jing J. Liu, Yang Zhang,,? and Xue Z. Wang*, (2017) Process Analytical Technology (PAT) Aided Identification of Operational Spaces Leading to Tailored Crystal Size Distributions in Azithromycin Crystallization via Coordinated Cooling and Solution Mediated Phase Transition. Organic Process Research & Development, 21 (12), 1963-1971.

  12. Yan Huo,Tao Liu, Xue Z. Wang, Cai Y. Ma and Xiongwei Ni, (2017) Online Detection of Particle Agglomeration during Solution Crystallization by Microscopic Double-View Image Analysis, Industrial & Engineering Chemistry Research, 56, 11257?11269

  13. Wen J. Liu, Cai Y. Ma, Jing J. Liu, Yang Zhang*, Xue Z. Wang*, (2017) Continuous reactive crystallization of pharmaceuticals using impinging jet mixers， AIChE Journal, 63: 967-974,

  14. Rui Zhang, Cai Y Ma, Jing J Liu, Yang Zhang, Yu J Liu and Xue Z. Wang*, (2017) Stereo Imaging Camera Model for 3D Shape Reconstruction of Complex Crystals and Estimation of Facet Growth Kinetics, Chemical Engineering Science, 160,171-182.

  15. Y Qin, C Zhao, X Wang and F Gao, (2017) Subspace decomposition and crtitical phase selection based cumulative quality analysis for multiphase batch processes, Chemical Engineering Science, 166: 130-143

  16. Chen Lin, Yang Zhang, Jing J Liu, Xue Z. Wang*, (2017) Study on nucleation kinetics of lysozyme crystallization, Journal of Crystal Growth, 469:59-64.

  17. Feng Lv, Jing J Liu, Yang Zhang and Xue Z Wang* (2017), Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation, Journal of Crystal Growth, 467: 155-161.

  18. Fangkun Zhang, Tao Liu, Yan Hou, Runduo Guan, Xue Z Wang (2017)Investigation of the operating conditions to morphology evolution of beta-L-glutamic acid during seeded cooling crystallization，Journal of Crystal Growth，469:136-143.

  19. Tao Liu, Yan Hou, Cai Y Ma, Xue Z Wang* (2017), Sparsity-based image monitoring of crystal size distribution during crystallization, Journal of Crystal Growth, 469: 160-167.

  20. Kui Wu, Cai Y. Ma, Jing J. Liu, Yang Zhang,* ,and Xue Z. Wang* (2016) Measurement of Crystal Face Specific Growth Kinetics, Crystal Growth & Design, 16,4855-4868.

  21. Ceyda Oksel, Vrishali Subramanian, Elena Semenzin, Cai Yun Ma, Danail Hristozov, Xue Z. Wang,* Neil Hunt, Anna Costa, Wouter Fransman, Antonio Marcomini and Terry Wilkins (2016) Evaluation of existing control measures in reducing health and safety risks of engineered nanomaterials, Environmental Science: Nano 3, 869-882.

  22. Ceyda Oksel, David A. Winkler, Cai Y. Ma, Terry Wilkins & Xue Z. Wang*(2016) Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approaches，Nanotoxicology, 10（7）1001-1012.

  23. Cai Y. Ma, Jing J. Liu and Xue Z. Wang*, (2016) Measurement, Modelling and Closed-loop Control of Crystal Shape Distribution: Literature Review and Future Perspectives, Particuology, 26, 1-18.

  24. Cai Y. Ma, Jing J. Liu and Xue Z. Wang* (2016) Stereo imaging of crystal growth, AIChE Journal 62 (1), 18-25

  25. JJ Liu, CY Ma, XZ Wang*, (2016) Imaging protein crystal growth behaviour in batch cooling crystallisation. Chinese Journal of Chemical Engineering 24 (1), 101-108

  26. Yan Huo, Tao Liu, Hui Liu, Cai Y. Ma, Xue Z. Wang, (2016) In-situ crystal morphology identification using imaging analysis with application to the l-glutamic acid crystallization, Chemical Engineering Science, 148, 126-139.

  27. 周昭露，李杰，黃生權，田淑華，劉玉嬌，魯亮，張揚，黃延盛，王學重*，(2016) 近紅外光譜技術在中藥質量控制應用中的化學計量學建模：綜述和展望， 化工進展，35(6), 1627- 1645

  28. 李杰，李傳坤，王春利，王學重, (2016) 基于優化動態 PLS 的常壓塔重整料終餾點軟測量研究, 計算機與應用化學, 33(3),06-39.

  29. Ceyda Oksel, Cai Y Ma, Jing J Liu, Terry Wilkins, Xue Z Wang* (2015) (Q) SAR modelling of nanomaterial toxicity: A critical review, Particuology 21, 1-19

  30. Wen J. Liu, Cai Y. Ma, Jing J. Liu, Yang Zhang, and Xue Z. Wang*,  (2015) Analytical technology aided optimization and scale-up of impinging jet mixer for reactive crystallization process, AIChE Journal, 61 (2), 503-517.

  31. Ceyda Oksel, Cai Y Ma, Xue Z Wang* (2015) Structure-activity relationship models for hazard assessment and risk management of engineered nanomaterials, Procedia Engineering 102, 1500-1510

  32. Rui Zhang, Cai Y Ma, Jing J Liu, Xue Z Wang*, (2015) On-line measurement of the real size and shape of crystals in stirred tank crystalliser using non-invasive stereo vision imaging， Chemical Engineering Science 137, 9-21.

  33. Yang Zhang, Yanbin Jianga,?, Duanke Zhanga, Yu Qiana, Xue Z. Wang*, (2015) Metastable zone width, crystal nucleation and growth kinetics measurement in anti-solvent crystallization of -artemether in the mixture of ethanol and water. Chemical Engineering Research and Design, 9(5): 187–194.

  34. Cai Y Ma，Jing J Liu，Yang Zhang，Xue Zhong Wang*，(2015) Simulation for scale-up of a confined jet mixer for continuous hydrothermal flow synthesis of nanomaterials，The Journal of Supercritical Fluids, 98, 211–221.

  35. C. Oksela, C.Y. Ma & X.Z. Wang*,  (2015) Current situation on the availability of nanostructure–biological activity data. SAR and QSAR in Environmental Research, 26(2), 79-94.

  36. Ratna Tantra*, Ceyda Oksel, Tomasz Puzyn, Jian Wang, Kenneth N. Robinson, Xue Z. Wang, Cai Y. Ma, Terry Wilkins, (2015) ..Nano (Q) SAR: Challenges, pitfalls and perspectives, Nanotoxicology 9 (5), 636-642

  37. Yang Zhang, Jing Jing Liu, Jian Wan, Xue Z. Wang*, (2015) Two dimensional population balance modelling of crystal growth behaviour under the influence of impurities, Advanced Powder Technology, 26 (2), 672-678

  38. R. Tantra*, C. Oksel, K.N. Robinson, A. Sikora, X.Z. Wang, T.A. Wilkins, (2015) A method for assessing nanomaterial dispersion quality based on principal component analysis of particle size distribution data. Particuology, 22, 30–38

  39. Yang Zhang, Jing J Liu, Lei Zhang, Xue Z Wang, (2015) Solubility of 2,5-Di-tert-butylhydroquinone and Process Design for Its Purification Using Crystallization, Journal of Chemical and Engineering Data, 60: 1968-1974.

  40. XZ Wang*, Y Yang, R Li, C Mcguinnes, J Adamson, IL Megson, (2014)， Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles. Nanotoxicology 8 (5), 465-476.

  41. CY Ma, M Chen, XZ Wang* (2014) Modelling and simulation of counter-current and confined jet reactors for hydrothermal synthesis of nano-materials， Chemical Engineering Science 109, 26-37.

  42. WJ Liu, CY Ma, SX Feng, XZ Wang* (2014) Solubility measurement and stability study of sodium cefuroxime. Journal of Chemical & Engineering Data 59 (3), 807-816.

  43. T Liu, XZ Wang*, J Chen (2014) Robust PID based indirect-type iterative learning control for batch processes with time-varying uncertainties. Journal of Process Control 24 (12), 95-106.

  44. Y Zhang, CY Ma, JJ Liu, T Liu, XZ Wang*, (2014) Modelling and simulation of counter-current reactors for continuous hydrothermal flow synthesis of nanoparticles, Dalian Ligong Daxue Xuebao (Journal of Dalian University of Technology), 54(6):662-675.

  45. T Liu, XZ Wang*, J Chen (2014) Robust PID based indirect-type iterative learning control for batch processes with time-varying uncertainties. Journal of Process Control 24 (12), 95-106.

  46. JJ Liu, YD Hu, XZ Wang*, (2013) Optimization and control of crystal shape and size in protein crystallization process. Computers & Chemical Engineering, 57, 133-140.

  47. A Falola, A Borissova, XZ Wang*, (2013) Extended method of moment for general population balance models including size dependent growth rate, aggregation and breakage kernels, Computers & Chemical Engineering 56, 1-11.

  48. R Quesada-Cabrera, X Weng, G Hyett, RJH Clark, XZ Wang, JA Darr*, (2013) High-Throughput Continuous Hydrothermal Synthesis of Nanomaterials (Part II): Unveiling the As-Prepared Ce x Zr y Y z O2? δ Phase Diagram. ACS Combinatorial Science, 15 (9), 458-463.

  49. Ma, C.Y., X.Z. Wang*, 2012, Model identification of crystal facet growth kinetics in morphological population balance modeling of l-glutamic acid crystallization and experimental validation Chemical Engineering Science, 70(5), 22-30

  50. Boonkhao, B., Li, R.F., Wang, X.Z.*, Tweedie, R.J., Primrose, K., 2011, Making use of process tomography data for multivariate statistical process control, AIChE Journal , 57 (9) , 2360-2368

  51. Wan, J., Wang, X.Z.*, Ma, C.Y, 2009, Particle shape manipulation and optimization in cooling crystallization involving multiple crystal morphological forms, AIChE Journal, 55 (8), 2049-2061

  52. Wang, X.Z.*, Ma, C.Y., 2009, Morphological population balance model in principal component space, AIChE Journal, 55 (9), 2370-2381

  53. Ma, C.Y., Wang, X.Z.*, 2009, Inductive data mining based on genetic programming: Automatic generation of decision trees from data for process historical data analysis, Comput & Chem Eng, 33 (10), 1602-1616

  54. Wang, X.Z.*, Liu, L., Li, R.F., Tweedie, R.J., Primrose, K., Corbett, J., McNeil-Watson, F.K., 2009, Online characterisation of nanoparticle suspensions using dynamic light scattering, ultrasound spectroscopy and process tomography, Chem Eng Res & Des, 87 (6), 874-884

  55. Wang, X.Z.*, Perston, B., Yang, Y., Lin, T., Darr, J.A., 2009, Robust QSAR model development in high-throughput catalyst discovery based on genetic parameter optimization, Chem Eng Res & Des, 87 (10), 1420-1429

  56. Ma, C.Y., Wang, X.Z*., 2008, Crystal growth rate dispersion modeling using morphological population balance, AIChE Journal, 54(9),2321-2334

  57. Wang, X.Z.*, Roberts, K.J., Ma, C., 2008, Crystal growth measurement using 2D and 3D imaging and the perspectives for shape control, Chem Eng Sci, 63 (5), 1173-1184

  58. Ma, C.Y., Wang, X.Z.*, Roberts, K.J., 2008, Morphological population balance for modeling crystal growth in face directions, AIChE Journal 54 (1), 209-222

  59. Wang, X.Z.*, Calderon De Anda, J., Roberts, K.J., 2007, Real-time measurement of the growth rates of individual crystal facets using imaging and image analysis: A feasibility study on needle-shaped crystals of L-glutamic acid, Chem Eng Res & Design, 85 A, 921-927

  60. Li, R.F., Thomson, G.B., White, G., Wang, X.Z.*, Calderon De Anda, J., Roberts, K.J., 2006, Integration of crystal morphology modeling and on-line shape measurement, AIChE Journal, 52 (6),2297-2305

  61. Calderon De Anda, J., Wang, X.Z.*, Lai, X., Roberts, K.J. , 2005, Classifying organic crystals via in-process image analysis and the use of monitoring charts to follow polymorphic and morphological changes, J Process Control, 15(7), 785-797

  62. Buontempo, F.V., Wang, X.Z.*, Mwense, M., Horan, N., Young, A., Osborn, D., 2005, Genetic programming for the induction of decision trees to model ecotoxicity data, J Chem Infor & Modeling, 45 (4), 904-912

  63. De Calderon Anda, J., Wang, X.Z.*, Lai, X., Roberts, K.J., Jennings, K.H., Wilkinson, M.J., Watson, D., Roberts, D., 2005, Real-time product morphology monitoring in crystallization using imaging technique, AIChE Journal, 51 (5), 1406-1414

  64. De Calderon Anda, J., Wang, X.Z.*, Roberts, K.J.,2005,Multi-scale segmentation image analysis for the in-process monitoring of particle shape with batch crystallisers, Chem Eng Sci, 60, 1053-1065

  65. Albazzaz, H., Wang, X.Z.*, 2004, Statistical process control charts for batch operations based on independent component analysis, Ind & Eng Chem Res, 43 (21), 6731-6741

  66. Mwense, M., Wang, X.Z.*, Buontempo, F.V., Horan, N., Young, A., Osborn, D., 2004, Prediction of noninteractive mixture toxicity of organic compounds based on a fuzzy set method, J Chem Infor & Computer Sci, 44 (5),1763-1773

  67. Chen, J., Wang, X.Z.*, 2001, A new approach to near-infrared spectral data analysis using independent component analysis, J Chem Infor and Computer Sciences 41 (4), 992-1001

  68. Garci?a-Flores, R., Wang, X.Z.*, Goltz, G.E., 2000, Agent-based information flow for process industries' supply chain modeling, Computers and Chem Eng, 24 (2-7), 1135-1141

  69. Chen, B.H., Wang, X.Z.*, Yang, S.H., McGreavy, C, 1999, Application of wavelets and neural networks to diagnostic system development ,2, an integrated framework and its application, Computers and Chem Eng, 23 (7),945-954

  70. Chen, B.H., Wang, X.Z.*, Yang, S.H., McGreavy, C, 1999, Application of wavelets and neural networks to diagnostic system development,1, feature extraction, Comput  Chem Eng, 23 (7), 899-906.

  71. Wang, X.Z., 1999, Data Mining and Knowledge Discovery for Process Monitoring and Control, Springer, London, New York.

  72. 王學重，馬才云，劉晶晶， 晶體三維晶面生長動力學的立體成像測定系統及方法，國家發明專利， CN103575734B， 2016.06.08。

  73. 王學重，馬才云，劉晶晶， 一種探頭式在線立體成像檢測系統及方法，國家發明專利， CN103558129B, 2016.02.24。

  74. 王學重，劉文菁，劉晶晶, 一種連續快速反應結晶提高晶體穩定性的裝置及方法, 國家發明專利， CN103551100A, 2015.10.28。

  75. 于帥，張揚，王學重，羅春，傅海燕，劉曉紅，劉丹青, 一種快速定量預測藥物穩定性的方法, 國家發明專利， CN107255646A, 2018.9.14。