
王敏,男,1987年12月出生,江蘇儀征人,理學博士,副教授,碩士生導師,畢業于中國科學院大學。現在新材料與化工學院制藥工程系工作。
I. 主要研究工作
1. 微生物天然產物(藥物)的挖掘;
2. 微生物天然產物生物合成機制;
3. 化學酶法合成重要藥物及其中間體。
II. 承擔科研項目
1. 微生物資源前期開發國家重點實驗室前沿探索課題基金:糖苷類化合物α、β構象轉換的研究,項目負責人,2019-2020。
2. 中國科學院微生物研究所科學研究基金:N-糖苷鍵構象的轉換及其機制的研究,項目負責人,2018-2021。
3. 國家自然科學基金青年科學基金項目:阿維菌素中L-齊墩果糖的生物合成機制研究(項目號:31700036),項目負責人,2018.01-2020.12。
4. 企業橫向項目:五肽熒光標簽的添加與結構表征,項目負責人,2024-2025。
5. 農業農村部植保生物技術重點實驗室開放基金項目:抗小麥病毒農藥先導化合物的挖掘,項目負責人,2024-2025。
III. 代表性學術論文
1. Haoyang Liu, Hailiang Xing, Peilan Yu, Yanjie Wang, Jia-Lei Yan, Junyang Liu,* Min Wang*. Base-Controlled Synthesis of Heteroatom-Embedded 9?��������Membered Cycloalkynes and 6?��������Membered Sultams through Copper-Catalyzed Cyclization[J]. J Org Chem, 2025, 90, 2, 984-993.
2. Yue Tang?��������, Xiaoying Tian?��������, Min Wang?��������, Yinglu Cui?��������, Yang She?��������, Zhaoxiang Shi, Jiaqi Liu, Huijin Mao, Lilu Liu, Chao Li, Yuwei Zhang, Pengwei Li, Yue Ma, Jinyuan Sun, Qing Du, Jie Li, Jun Wang, De-feng Li, Bian Wu*, Feng Shao*, Yihua Chen*. The β-D-manno-heptoses are immune agonists across kingdoms[J]. Science, 2024, 385, 678-684.
3. Yunqiang Wu, Min Wang*, Liwei Liu*. Advances on structure, bioactivity, and biosynthesis of amino acid-containing trans-AT polyketides[J]. Eur J Med Chem, 2023, 262, 115890.
4. Yuwei Zhang#, Ge Liao#, Min Wang#, Zhao Zhang#, Liwei Liu, Yuqin Song, Dacheng Wang, Tingting Hao, Jie Feng, Bin Xia, Yixiang Wang, Xiaoyu Tang*, Yihua Chen*. Human?��������associated bacteria adopt an unusual route for synthesizing 3?��������acetylated tetramates for environmental adaptation[J]. Microbiome, 2023, 11: 97.
5. Peishan Li#, Hongmei Lu#, Yanzhu Zhang, Xuejiao Zhang, Lianliang Liu, Min Wang*, Liwei Liu*. The natural products discovered in marine sponge-associated microorganisms: structures, activities, and mining strategy[J]. Front Mar Sci, 2023, 10: 1191858.
6. Li Tao#, Min Wang#, Guobo Guan, Yuwei Zhang, Tingting Hao, Chao Li, Shuaihu Li, Yihua Chen, Guanghua Huang*. Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid[J]. Virulence, 2022, 13:1, 542-557.
7. Yue Tang#, Min Wang#, Hua Qin, Xiangxiang An, Zhengyan Guo, Guoliang Zhu, Lixin Zhang, and Yihua Chen*. Deciphering the Biosynthesis of TDP-β-L-oleandrose in Avermectin[J]. J Nat Prod, 2020, 83: 3199-3206.
8. Min Wang#, Zhoujie Xie#, Shoubin Tang#, Ee Ling Chang, Yue Tang, Zhengyan Guo, Yinglu Cui, Bian Wu, Tao Ye, Yihua Chen*. Reductase of mutanobactin synthetase triggers sequential C-C macrocyclization, C-S bond formation, and C-C bond cleavage[J]. Org Lett, 2020, 22: 960-964.
9. Jine Li#, Min Wang#, Yong Ding, Yue Tang, Zhiguo Zhang*, Yihua Chen*. Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins[J]. Sci Rep, 2016, 6: 21180.
10. Tao Ji#, Yanjie Wang#, Min Wang#, Ben Niu#, Ping Xie, Charles U. Pittman, Jr., and Aihua Zhou*. Parallel syntheses of eight-membered ring sultams via two cascade reactions in water[J]. Acs Comb Sci, 2013, 15: 595-600.
11. Min Wang, Yanjie Wang, Xueyong Qi, Guohua Xia, Kun Tong, Jinchang Tu, Charles U. Pittman Jr., and Aihua Zhou*. Selective synthesis of seven- and eight-membered ring sultams via two tandem reaction protocols from one starting material[J]. Org Lett, 2012, 14: 3700-3703.
IV. 發明專利和軟件著作權
1. 陳義華,唐越,王敏。一類保羅霉素衍生物及其制備方法與應用(ZL201810677960.X)。
2. 劉磊,陳天鴿,徐巨才,許敏,徐振崗,陳韜文,干雨澤,魏萍,王敏,袁兆棟,賀天懿。具有緩釋維生素作用的特殊醫學用途配方食品的加工方法(CN 117158578 B)。
3. 劉君羊,劉昊洋,邢海亮,王敏。一種六元環磺酰胺類化合物的制備方法202410937674。
V. 招生信息
本人目前主要招收生物與醫藥(0860)專業學位碩士。誠摯歡迎化學、中藥、生物制藥、藥學等專業踏實認真、敢于創新的同學加入本團隊。